Acute Systemic Infusion of Bupropion Decrease Formalin Induced Pain Behavior in Rat
Korean Journal of Pain 2014³â 27±Ç 2È£ p.118 ~ p.124
(Naderi Somayyeh) - Urmia University of Medical Sciences Faculty of Medicine Danesh Pey Hadi Co
(Pakdel Firouz Ghaderi) - Urmia University of Medical Sciences Faculty of Medicine Neurophysiology Resaerch Center
(Osalou Mostafa Ashrafi) - Dokuz EyluL University School of Medicine Department of Histology & Embryology
(Cankurt Ulker) - Dokuz EyluL University School of Medicine Department of Histology & Embryology
Abstract
Background: The chronic pain can disturb physical, psychological, and social performances. Analgesic agents are widely used but some antidepressants (ADs) showed analgesia also. Bupropion is using for smoke cessation but it can change morphine withdrawal signs such as pain. This study tested the acute systemic effect of bupropion on formalin induced pain behavior in rats.
Methods: Wistar male healthy rats were divided into 7 groups (control, sham, and 5 treated groups with 10, 30, 90,
120, and 200 mg/kg of bupropion, i.p.). The bupropion injected 3 hours prior to formalin induced pain behavior. Formalin (50 ¥ìl, 2.5%) was injected subcutaneously in dorsal region of right hindpaw in all animals. Nociceptive signs were observed continuously on-line and off-line each minute. Common pain scoring was used for pain assessment.
Results: The analysis of data by one-way ANOVA showed that bupropion can reduce pain scores in the second phase but not in first phase. Bupropion decreased the licking/biting duration significantly in first and second phase of formalin test.
Conclusions: The results showed that bupropion has analgesic effects at systemic application. The change of second phase of the pain behavior was significant and it revealed that central mechanisms involve in bupropion analgesia.
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analgesia, antidepressant, bupropion, formalin test, pain, rat
KMID :
0363120140270020118
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